Pharmacokinetics of the seroteninergic anorectic agent, Essay

Pharmacokinetics of the seroteninergic anorectic agent, dexfenfluramine - Essay Example Serotoninergic anorectic agent, dexfenfluramine acts to increase the serotonin level in extracellular space of the brain causing reduced appetite. This effect promotes its use in obesity treatments. Its ability to, dissolve in lipids provide easier transportation across blood brain barrier. Scientists developed dexfenfluramine, dextrorotary stereoisomer of fenfluramine to reduce the side effect of fenfluramine, developed in 1960s and marketed as pondimin. Approval of dexfenfluramine by FDA took place in 1976 but its introduction to market took place later in 1995 by Wyeth since fenfluramine had shown to cause hypertension in some people using it to fight obesity. Later withdrawal on September 15, 1997 from US market was due to side effect associated with heart problems. Dexfenfluramine is a synthetic anti-obesity chemical with molecular weight of 267.7, white crystalline powder, with high solubility saline solution, alcohol and chloroform. Dexfenfluramine has a solubility of 100nm in water. It also acts to decrease the growth hormones such as leptin and insulin but lead to increase in gherlin. Dexfenfluramine is more potent in inhibition of serotonin reuptake than active metabolite nordexfenfluramine. However, it is less potent in acceleration of serotonin release into the synaptic cleft. Administration of dexfenfluramine is mainly through oral, inhalation routes and lesser extent intravenous infusion in compound called dexfenfluramine hydrochloride (C12H16F3N,HCl)1. Oral administration of compound under the name of ‘redux’ was in capsules enclosing white crystalline powder weighing 15mg. The oral route is favoured due to resistance of dexfenfluramine to acidic media in the stomach. In addition, the hydrophobic nature of the drug is favours diffusion through the gastro intestinal walls. In some cases though rare,

Haitian Culture Assignment Example | Topics and Well Written Essays - 1250 words

Haitian Culture - Assignment Example Additionally, another small portion include the Hindus as well as Muslims who commonly presently inhabit Port-au-Prince (Largey, 2012, p.14-15). Generally, most Haitians exhibit a significant link to the event of the 1804 expulsion of the French, an occurrence that led to Haiti being the first sovereign Black state as well as being second in the Western Hemisphere to attain self-rule from imperial Europe. Haitian’s culture depicts the meaning of touch in various forms. This is quite evident among the male gender whereby they exhibit a tendency of holding hands in public. For outsiders, this action may be a depiction of homosexuality. For Haitians, however, holding hands in pubic portrays friendship but it is extremely rare for them to show affection publicly towards their females for this to them ought to be in privacy. Affection towards, family members may be shown overtly and holding hands of family members may not be regarded inappropriate (Migraine-George, & Jackson, 2014, p.7-8). Further, in the case of professionals, for instance, health-care providers, physical contact only comes as a result of shaking hands whereby actions like kissing regard them as inappropriate. However, touch by health-care providers during service provision normally receives appreciation. With regards to personal spatial and distancing strategies, most Haitians do not mind so much about personal space. Therefore, in most instances, interaction tends to be close, be it with a friend or a family member. Generally, compared to Americans require less personal spatial thus in most cases they position themselves closer to one another when communicating. Further, during a conversation, for most Haitians, direct eye contact is considered appropriate especially when used with friends or persons of same age group as well as family members.